Precision medicine, an approach to patient care that is tailored to the individual, is an attainable goal. A key component of precision medicine is a patient’s genes and how their genes influence their risk of disease & progression and their response to treatment. NashBio’s data covers both the phenotypic and the genotypic patient data, enabling the interrogation of these interactions.
Smarter data that enables precise medical care
An understanding of genes and how they influence and interact with disease is so critical that it materially impacts (2-7x) the success rate of clinical trials¹.
Genetic Data by the Numbers
DNA samples from the BioVU® biobank were assayed on Illumina's Expanded Multi-Ethnic Genotyping Array (MEGAEX). MEGAEX covers 2 million variants and was developed to provide extensive genotyping coverage of European, East Asian and South Asian populations. The genotype data is available in PLINK format.
*NashBio acknowledges the complexities surrounding ancestry, genetic ancestry calculations and the use of ancestry in genomic analysis. Here we classify the population into relative majority 1000 Genomes super-groups.
Imputed Data
Less anomalies for enhanced usability
Imputing genomic datasets can greatly increase the number of represented variants and can enhance genomic analyses, such as genome-wide association studies. NashBio has imputed the 90,000-subject MEGAEX dataset using multiple industry-standard pipelines (Michigan, TOPMed) and multiple reference datasets (1000 Genomes, HRC, TOPMed). The imputed datasets include between 30 million and 300 million variants (15x-150x MEGAEX). Imputed datasets are available in PLINK format for EUR and AFR ancestry cohorts.