Bespoke Projects - Nashville Biosciences

Bespoke Projects

Creating Custom Developed Solutions for Your Use Case

Advancing the discovery and development of new therapeutics and diagnostics by making complex real-world data (RWD) easy to use. Let our team of experts navigate your solution. The NashBio team focuses on tailoring a multimodal dataset to your unique specifications to meet your discovery needs and achieve an optimal return on your clinical and operational investments.

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NashBio’s bespoke solutions are trusted by organizations worldwide — see what some of our clients have to say about working with us:

“…We have already started to make discoveries about variants in the human genome that correlate with very important diseases that we could not have made without having access to the data coming out of NashBio.” – Large Pharma Customer

“Here’s a chance to take the information and study a human in the context of longitudinal electronic medical records.” – Large Pharma Customer

“To have association between some genes and then some phenotypes… it will contextualize the information you gain from the genetic data.” – Large Pharma Customer

Patient Demographics

4M

patients

4.1 years

median length of patient EHR

6 visits

median per patient

EHR-Reported Race

EHR-Reported Gender

Age at Last EHR

Smarter Data That Enables Deeper Analysis and Discovery

Large-scale association analyses are commonly performed to link phenotypic and genomic datasets. Study findings may elucidate new targets for drug discovery or new patient populations that would benefit from repurposing an existing therapeutic. Nashville Biosciences’ 250,000 whole genome sequences + linked de-identified electronic health records dataset serves as the substrate for our association studies.

Example Projects

Genome-wide association studies (GWAS)

Nashville Biosciences works with our customers to define appropriate case and control cohorts, balancing cohort refinement with adequate sample size. A GWAS package includes a statistical output file (e.g., P-values, odds ratio, variant), Manhattan plots and Q-Q plots.

Phenome-wide association studies (PheWAS)

Nashville Biosciences can deliver precomputed PheWAS data from the entire dataset or perform a custom PheWAS analysis based on the genes and variants of interest to our customers. A PheWAS package includes a statistical output file (e.g., P-values, odds ratio, variant) and Manhattan plots.

Our clients and partners include many of the world’s leading health care organizations:

Use Cases

Our use cases demonstrate how our data, expertise, and insights can improve the success rates of clinical research to accelerate scientific discoveries.

Identifying novel drug targets for pain relief using genomics and real-world data

Improving AI-guided clinical decision support with enriched data and industry expertise

Developing predictive diagnosis algorithms using electronic health records

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Case Studies

These case studies illustrate how we leverage our expansive dataset and expertise to develop innovative solutions for our clients.

Disease Risk Modeling

Acute pancreatitis has become increasingly prevalent across the world, affecting nearly 85,000 individuals annually. Patients with acute pancreatitis experience significant rates of mortality in the emergency department…

Molecular Data Generation

Improving Early-Stage Drug Discovery Process. We worked with Pfizer’s Target Sciences and Technologies group to explore genetic targets for treating a serious metabolic disease with greatly increasing prevalence…

Genetic Data Retrieval Tool

Assessing pain-associated SNPs through the linkage of genetic and clinical information. Hereditary neuropathies are a group of peripheral nervous system disorders that are characterized by numbness…

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