Large-scale association analyses are commonly performed to link phenotypic and genomic datasets. Study findings may elucidate new targets for drug discovery or new patient populations that would benefit from repurposing an existing therapeutic. Nashville Biosciences’ 90,000-subject MEGAEX + linked de-identified electronic health records dataset serves as the substrate for our association studies.
Smarter data that enables deeper analysis and discovery
GWAS & PheWAS Studies
Genome-wide association studies (GWAS)
Nashville Biosciences works with our customers to define appropriate case and control cohorts, balancing cohort refinement with adequate sample size. A GWAS package includes a statistical output file (e.g., P-values, odds ratio, variant), Manhattan plots and Q-Q plots.
Phenome-wide association studies (PheWAS)
Nashville Biosciences can deliver precomputed PheWAS data from the entire dataset or perform a custom PheWAS analysis based on the genes and variants of interest to our customers. A PheWAS package includes a statistical output file (e.g., P-values, odds ratio, variant) and Manhattan plots.